Kyle Hogg claimed career-best figures of 7-27 as Lancashire picked up where they left off against Essex last week by bowling out County Championship Division Two leaders Northamptonshire for just 62 at Old Trafford.
After skittling Essex for a record-low 20 at Chelmsford, Red Rose duo Hogg and Glen Chapple bowled all 29.5 overs as they ripped through Northants on day one of their clash.
Skipper Chapple, who last week took five wickets for just nine runs, began the rout after putting Northants in, having Kyle Coetzer caught by Andrea Agathangelou at second slip off just the fourth ball of the day.
Hogg claimed his first in the next over as he trapped David Sales lbw and he repeated the trick to dismiss Alex Wakely to leave Northants 9-3. Rob Keogh was next to go as he edged Hogg to wicketkeeper Gareth Cross before James Middlebrook was bowled by Chapple.
Hogg then claimed his fourth before lunch when Andrew Hall was given out lbw for 10 to reduce the visitors to 40-6 at the interval. After the break, the 29-year-old seamer was quickly back in the action as David Willey edged him to Tom Smith at slip and he then bowled former Lancashire team-mate Steven Crook for an innings best 16.
Chapple then wrapped up the innings as Ashwell Prince took a catch in the slips to dismiss Graeme White for a duck before the Lancashire captain sent Mohammad Azharullah's middle stump flying.
But the visitors hit back as the wickets continued to tumble, with Lancashire reduced to 121-8 in reply when bad light forced play to be abandoned with 15.3 overs left in the day.
Luke Procter bowled by Pakistan-born Azharullah in the second over and former South African Test batsman Prince was lbw to Willey in the ninth.
Willey then bowled Luis Reece for 16 before Simon Katich (30) and Agathangelou put on 44 - the highest partnership of the day - to steady the ship and take the hosts to 85-3.
But when Hall broke the stand by bowling Cypriot Agathangelou for 21 it began a collapse which saw five wickets fall for 16 runs to reduce the hosts to 101-8 before Stephen Parry and Smith extended Lancashire's lead to 59 before play was abandoned for the day.