England internationals James Anderson, Stuart Broad and Matt Prior will make their first appearances of the summer when the latest round of the County Championship gets under way on Wednesday.
Seam bowler Broad will lead Nottinghamshire's attack away at Derbyshire in the first meeting of the midlands rivals in the championship since 2007.
Derbyshire, newly promoted to the top flight this season, need an instant response from their batting line-up after they were dismissed for 60 in their second innings on the way to a nine-wicket defeat to Middlesex at Lord's last week.
Nottinghamshire lost their opening game of the season at home to early Division One leaders Middlesex but found form by thrashing the Durham MCCU - Samit Patel taking a particular liking to the students' bowling with 256 not out.
Wicketkeeper Prior is available for Sussex's trip to take on Surrey, a game which will also see Rory Hamilton-Brown and Chris Jordan returning to The Oval face their former county.
Fast bowler Chris Tremlett is fit and available for Surrey after putting a year of injury troubles behind him - at one point England's 2010-11 Ashes hero was struggling to even get out of bed.
Yorkshire have Joe Root, Jonny Bairstow and Tim Bresnan in the ranks for their trip to Durham, who slumped to 94 all out chasing 413 against defending champions Warwickshire last week.
But the Tykes are without spinner Azeem Rafiq for six weeks due to a knee problem, meaning all-rounder Adil Rashid is likely to be recalled.
There is a little treat for county fans from Thursday to Sunday when the Sky Sports cameras will be at Taunton for live coverage of Somerset versus Warwickshire, the top two sides last season.
Warwickshire must again do without England batsmen Jonathan Trott and Ian Bell on the orders of the England and Wales Cricket Board.
In the lower tier, Anderson's presence boosts Lancashire, who welcome Kent to Old Trafford.
Division Two leaders Northamptonshire have the chance to stretch their advantage when they travel to Gloucestershire, while down in Southampton Hampshire and Worcestershire are targeting their first win of the campaign.