Yorkshire will be without Jack Brooks for their clash with reigning champions Warwickshire in the LV= County Championship after the seamer suffered a broken bone in his left thumb.
The ex-Northamptonshire bowler picked up the injury in the draw with Somerset at Headingley last week and is expected to be sidelined for six weeks.
As well as Brooks, the in-form Tykes are also without England trio Jonny Bairstow Tim Bresnan and Joe Root for the Division One game at Edgbaston.
However Ryan Sidebottom and Liam Plunkett are both in contention for a return and if any of their international players aren't picked for the first Test against New Zealand, they could be drafted into the XI on day two.
The hosts have lost Jonathan Trott and Ian Bell, but Varun Chopra, Chris Woakes and Chris Wright are welcomed back after missing the rain-hit draw with Middlesex to play for the England Lions.
Elsewhere in the top tier, Surrey will be looking to bounce back from their home loss to Durham on Monday when they travel to Trent Bridge to face Nottinghamshire; Jade Dernbach, Jon Lewis and Chris Tremlett could all be drafted in to boost the London county's bowling attack.
Nottinghamshire are still without Andre Adams and will have to make at least two changes to the side that lost to Durham in their last Championship outing, as both Stuart Broad and Graeme Swann are now with England.
Sussex have Australian seamer Steve Magoffin back in their squad to face bottom county Derbyshire in the other Division One game to start on Wednesday.
There are also two games getting underway in the second tier; leaders Northamptonshire look likely to hand a four-day debut to former Surrey batsman Martin Spriegel when they welcome Leicestershire to Wantage Road.
The hosts cannot call upon Kyle Coetzer and David Murphy as they are away with Scotland, though Rob Newton is fit to play after overcoming a groin strain and Ben Duckett will take over from Murphy behind the stumps.
Essex, meanwhile, are missing England skipper Alastair Cook and Australian batsman Rob Quiney, who is due to have an operation on the shoulder he injured fielding in the defeat to Lancashire, for the game against Glamorgan.
Reece Topley is also a doubt but Ravi Bopara does return after playing for England Lions against the touring Kiwis last week.