Ashwell Prince scored a century but could not prevent Lancashire from losing to Nottinghamshire on their return to Division One of the LV= County Championship.
Chasing a victory target of 349 the visitors resumed on 7-1 with batting out the final day for a draw uppermost in their minds, but Prince's 100 in 181 balls raised the possibility of a shock win.
Together with Tom Smith (76) he shared the best stand of the match, putting on 147 for the seventh wicket as he looked like making Nottinghamshire (21pts) pay for twice missing opportunities to remove him early on.
But the second new ball sparked a turnaround for the hosts, Smith out second delivery with Luke Fletcher inducing an edge to Riki Wessels at slip and new batsman Wayne White departed lbw to the same bowler.
Prince reached three figures but was last man out as Harry Gurney (4-81) took out his leg stump and ended proceedings. Lancashire take three points.
Sussex made a flying start to the Division One season and laid down a marker in the process with a comprehensive innings and 27-run victory over Middlesex at Hove.
Needing to bat out the final day to snatch a draw, Middlesex failed to reach lunch as they lost nine wickets for 97 runs to complete a miserable first outing of the summer.
Just as was the case in the first-innings when they were bundled out for 105, Middlesex fell foul to Sussex's seam attack, who shared all second innings wickets between them as they posted just 154 in their second knock.
Australian seam bowler Steve Magoffin took 5-56, Joe Anyon claimed 3-67 and Jon Lewis capped an impressive debut with 2-21.
Sussex collected 23 points for the win, while Middlesex return to the capital with only three.