Nottinghamshire paceman Jake Ball has been ruled out of Saturday's Yorkshire Bank 40 final against Glamorgan.
The Outlaws' joint-leading wicket-taker will sit out the Lord's showdown due to a back injury, although he is set to be replaced by England's Stuart Broad.
Ball reported that he was feeling "significant discomfort" in his back and had no chance of recovering in time to feature at headquarters.
"Saturday's game would have been the biggest occasion of my career and I am devastated to be missing it," said Ball.
"It's not a serious injury but the game is of such importance that it would be wrong for me to take my place knowing that I can't give 100 per cent.
"I will be the team's biggest supporter on the day and I know that they will be doing all that they can to win the trophy."
Notts director of cricket Mick Newell added: "Jake would have been in the team given his performances in the competition this season but his injury isn't getting any better.
"We want to maintain the same balance in the team so three quick bowlers will play and it's very unfortunate that Jake can't be considered."
Notts confirmed that Broad, who was rested for the recent NatWest Series defeat to Australia, is now a "virtual certainty" to start.
Live coverage of Saturday's YB40 final starts at 11am on Sky Sports 2 HD