Ben Stokes' run of injuries has continued with the Durham all-rounder facing three weeks on the sidelines due to a knee complaint.
Stokes is set to see a specialist to ascertain the extent of the damage after his knee became swollen.
The 20-year-old, who made his international debut last summer, had been due to play for the England Lions against West Indies in their ongoing match at Northampton, but was initially sidelined by a back problem.
He had an injection to help clear that complaint on May 9, with his county Durham hoping he would be available for their Clydesdale Bank 40 match against Somerset.
"He's probably going to miss two or three weeks," said Durham coach Geoff Cook.
"One day he turned up and his knee has swelled up."
After undergoing scans an England and Wales Cricket Board spokeswoman confirmed that Stokes will undergo a consultation with a specialist next week.
Depending on the outcome of that meeting he may not be able to play until June, which would leave him little time to prove his fitness ahead of the one-day international series against the Windies.
Stokes would also miss Durham's next three Clydesdale Bank 40 games as well as their County Championship match against Lancashire, which begins on May 30.
Stokes, who has made seven limited overs appearances for England, was hindered by a finger complaint for a large chunk of last season before his latest injury worries.