England have called Jonathan Bairstow and Jos Buttler into their NatWest Series squad after Ben Stokes suffered a recurrence of a finger injury.
Durham batsman Stokes has played in each of England's four matches so far against India.
England are already 2-0 up, after a no-result at Chester-le-Street and then a tie at Lord's on Sunday, but have been disrupted by two other injuries already, which reduced them to 12 fit men to choose from - before Stokes was hit during batting drills on Thursday.
Eoin Morgan and Stuart Broad both succumbed to shoulder problems, and Stokes took a blow to the right index finger he broke earlier this year and which has prevented him bowling since.
Uncapped Yorkshireman Bairstow is thought to be the most likely to replace Stokes, if necessary - while Buttler, who was playing in the final day of Somerset's match against Lancashire at Taunton on Thursday, is called in as more general cover.