England will be without pace bowler Stuart Broad for the first two one-day internationals against South Africa.
The 23-year-old has failed to shake off the shoulder injury which has kept him out of the recent Twenty20 series and Tuesday's 50-over warm-up victory over South Africa 'A'.
Broad picked up the injury whilst fielding during the opening tour match against the Diamond Eagles in Bloemfontein.
The Nottinghamshire all-rounder will be rested for Friday's opening ODI at the Wanderers, as well as the second ODI at Centurion on Sunday.
Andy Flower's men have, however, been boosted by the news that both Paul Collingwood and James Anderson should be fit for Friday's opener in Johannesburg.
Collingwood picked up a back injury during his side's Twenty20 victory over South Africa at the Wanderers, but told reporters he is close to full fitness.
He said: "(The injury) is actually progressing really well. It was very, very sore on Sunday and I had two injections on Monday.
"If I was playing today I would have been 50-50, but I've got a couple of days to go so the chances are going to be very high.
"Everything seems to have settled down, I'm doing the work in the gym and progressing really well, so I've got a very good chance for Friday."
Should Collingwood return to the starting XI, he will become England's most capped one-day player of all-time, surpassing the 170 appearances he currently shares with Alec Stewart.
Strike bowler Anderson is also expected to return to the fold after shrugging off a knee injury in time to take on the Proteas.
And Collingwood has described having the Lancastrian available for Friday's opening ODI as "crucial".
"I think we're aggressive as a unit, I think we're getting more experience and we've obviously got Jimmy Anderson to come back into the side, which is crucial," he said.
"I think he's a real kind of leader for us now in terms of the bowling stakes. For such a young guy, I know that's a big statement, but he is a real leader in bowling.
"But again, we've got a lot of potential and very dangerous bowlers, obviously with Broady coming back in as well. We have missed those two when they were injured.
"Hopefully they will be fit pretty soon and we can get back to bowling sides out."