West Indies duo Dwayne Bravo and Xavier Marshall have been ruled out of the Stanford Superstars squad for the upcoming Twenty20 match against England.
The decision, which means that both players will miss out on cricket's biggest pay day, was announced by the Chairman of the Stanford Superstars Selection Panel, Sir Viv Richards, on Tuesday.
West Indies all-rounder Darren Sammy and 31-year-old batsman Travis Dowlin, who has not appeared on the international stage, have been called up as replacements.
Bravo's omission had been expected after he underwent surgery on his troublesome left ankle late last month.
The 24-year-old all-rounder had planned to have the operation following the Stanford series, but opted to bring the procedure forward after it prevented him from playing in last month's Tri-Nations series in Canada.
However, Richards did not give any explanation for Marshall's absence.
The 22-year-old right-hander, who hit a one-day international record 12 sixes in an innings against Canada last month, appeared in a local Jamaica league match at the weekend.
The Stanford Superstars squad will assemble in Antigua on Thursday to begin a six-week preparatory training camp under the guidance of head coach and former West Indies international Eldine Baptiste.
Shivnarine Chanderpaul, named the International Cricket Council's Cricketer of the Year last week, will be the only member of the 17-man squad not to join the team as he finishes the English domestic season with Durham.
The Stanford Superstars will play England on November 1st, with prize money of $20 million (£11.2million) representing the largest payout in the history of team sport.