Dale Steyn and Jacques Kallis have been released from South Africa's squad ahead of the third ODI against Pakistan after failing to overcome niggling injuries.
Paceman Steyn, who has a mild side strain, and all-rounder Kallis, who has a sprained joint in the little finger of his right hand, have been given time to rest ahead of the forthcoming series against India.
The Proteas are already 2-0 down in the three-match series, with team manager Mohammad Moosajee currently steering his side through a busy limited-overs programme which includes 11 ODIs and four T20s within six weeks, culimating in a three-match ODI series against India starting next week.
Steyn has struggled with side strain problems for much of the year and looked in discomfort during Sunday's first ODI in Cape Town, although he played in the second match in Port Elizabeth on Wednesday.
Kallis' injury has come after a return to the one-day side following two years away with a view to competing in the 2015 World Cup.
He replaced Faf du Plesiss and scored a half-century in Cape Town, but will now miss the final game of the series.
Wayne Parnell could come in as an additional all-rounder for the hosts, with Morne Morkel or Vernon Philander battling to replace Steyn.