South Africa strike bowlers Dale Steyn and Morne Morkel face a battle to be fit for Monday's crucial Champions Trophy clash with Pakistan at Edgbaston.
Steyn missed the Proteas' 26-run defeat to India in their Group B opener in Cardiff due to a side strain, while Morkel is to go for a scan after he pulled up with a quad strain just 6.5 overs into his allocation.
Team manager Dr Mohammed Moosajee said: "Morne Morkel sustained a left quadricep muscle strain while bowling and left the field immediately.
"It appears to be a grade one strain and he will be going for an MRI scan which will give us a better understanding of the diagnosis and a prognosis.
"Dale Steyn sustained a side strain in a warm-up game (against Pakistan on Monday), these strains can be tricky in fast bowlers and the healing time in most cases is five to seven days, but if you come back too soon it can cause further disruption and set you back 10-14 days."
South Africa captain AB de Villiers admitted crucial errors, including two farcical run-outs, had proved costly.
He said: "The run-outs were unforced. In the heat of battle sometimes you are not on the same wavelength as your partner and unfortunately there were a couple of misunderstandings and it cost us dearly.
"We now have a very important game against Pakistan. We are going there to win and we have to keep the aggressive mind-set that we had in Cardiff.
"It's do or die. If you win only one group game net run-rates and things like that come into play and we do not want that.
"We ideally need to win two out of our three games. It's a short tournament and there's no room for error after losing to India.
"We will try to correct that in the next game and go for a big one."
Shikhar Dhawan's 114 - his maiden one-day international century - provided the backbone to India's 331-7.
Dhawan said: "I am really happy with how I played this innings and even more happy we got a good win against South Africa and we can build for our next games.
"Even without Morkel and Steyn, South Africa's bowlers have experience on the international circuit and they bowled good pace, but Rohit (Sharma) and I played really sensibly at the start and then used the pace of their bowling to play some good shots."
Who will win the 2013 ICC Champions Trophy?