Jacques Kallis has withdrawn from South Africa's ICC Champions Trophy squad for personal reasons.
The all-rounder has not been included in a final 15-man party for next month's tournament, though the full reasons for his omission remain unspecified.
JP Duminy is in the squad after six months of rehabilitation from ankle and Achilles injuries, while left-hander David Miller has been earmarked as the man to fill Kallis' boots in the middle order.
"Jacques' experience will obviously be missed but it does create an opportunity for David Miller, whose recent form has been most impressive," said selector Andrew Hudson.
"It also gives a young player the chance to make his mark ahead of the ICC World Cup in 2015."
Of Duminy, he said: "JP is well on the way to a full recovery. The latest information is that he will be fully fit to play his part in all three disciplines by the end of the month.
"He is a very experienced limited-overs cricketer and we don't anticipate his lack of match practice being any kind of problem.
"His return adds a lot of balance to the side and that, together with the presence of two batting all-rounders in Faf du Plessis and Farhaan Behardien, means that we now have the option to go into the tournament with seven specialist batsmen."
Slow bowlers Imran Tahir and Roelof van der Merwe are among the players to miss out from a provisional squad of 30.
Hudson said: "As always there are unlucky players. Unfortunately we can only take 15 players to England.
"However, the World Cup is two years away in Australasia and is a wonderful incentive for those who have missed out to concentrate their focus."
Squad: De Villiers (captain), H Amla, F Behardien, JP Duminy, F du Plessis, C Ingram, R Kleinveldt, R McLaren, D Miller, M Morkel, R Peterson, A Phangiso, G Smith, Dale Steyn, L Tsotsobe.
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