Steven Finn impressed in his first County Championship outing of the season at Lord's with a haul of 4-36 that left Derbyshire reeling on 205-9 at stumps on the opening day.
With national selector Geoff Miller and England team director Andy Flower both watching events from the Lord's Media Centre, Finn and his Middlesex pace attack partners of Tim Murtagh, Toby Roland-Jones and Gareth Berg overcame a frustrating first session to run through the visiting top order after lunch.
While Finn conceded only five runs in his opening seven-over burst, Murtagh might have removed opener Billy Godleman with the Derbyshire total on three - as it was Godleman was put down by Sam Robson at slip and went on to survive 354 minutes for an overly cautious 55.
Without addition to the total, Derbyshire did lose Wayne Madsen in a farcical manner. Having dug out a quick full-length ball from Finn, Madsen set off looking for a single. But the ball cannoned off the pads of Godleman at the non-striker's end and into the path of Chris Rogers, whose direct hit from mid-off to the striker's end ran out Madsen before he could regain his ground.
Godleman joined forces with Wes Durston to add 83 for Derbyshire's second wicket in 36 overs either side of lunch before Finn struck 10 overs after the break, bagging his 300th first-class wicket in the process.
Just two short of his half-century Durston's 140-minute stay ended with a lazy pull shot against the England paceman that flew to long leg.
Middlesex were celebrating again after claiming the prized scalp of Derbyshire's overseas star and the world's number two rated batsman, Shivnarine Chanderpaul, for 18. Checking a pull shot against Berg, the West Indies left-hander chipped to midwicket where Joe Denly pocketed a simple catch.
Derbyshire's demise continued when Dan Redfern (15) wafted at a leg-side delivery from Finn to feather to wicketkeeper John Simpson, who bagged another scalp two overs later when Chesney Hughes (4) chased a wide one from Finn to snick a leaden-footed back-foot waft.
Finn picked up his fourth wicket with a full-length in-ducker that snared Jonathan Clare (6) leg before on the back foot to make it 150 for six but, in the best conditions of the day, Godleman teamed up with Tom Poynton to add another 30 for the seventh wicket in an hour.
Poynton (16) edged to the keeper to gift Roland-Jones a late wicket then Tony Palladino ran himself out without facing a ball to toss away yet another wicket after Godleman refused a second run.
Godleman batted almost six hours and scored only one boundary in his 265-ball stay before Murtagh returned six overs from stumps to trap him leg before.
His stoic 244-ball half-century in 323 minutes was one of the slowest ever in the history of county cricket.