South Africa captain Graeme Smith said that winning two successive series in Australia was his finest moment in cricket.
The Proteas thrashed Australia by 309 runs in the third Test on Monday to hold onto their No 1 ranking and take the three-match series 1-0.
South Africa are the first team in two decades to defeat Australia on home soil in consecutive tours, with the West Indies the last to achieve it in 1992-93.
"It has been a tremendous effort," said Smith. "I am extremely humbled. For us it means the world, there are people in our set-up who have taken many beatings on tours of Australia.
"We know what is required to win here, we have been a part of something really incredible and special. This is the proudest achievement of my career."
Hashim Amla picked up the man of the match award in the third Test after a superb second-innings knock of 196 off 221 balls, which took him past 1,000 Test runs in 2012.
Amla enjoyed stands of 178, 81 and 149 with Smith, Jacques Kallis and fellow centurion AB de Villiers.
"I am just glad to make a contribution in a winning cause," he said.
"Experience always helps. I'm very fortunate that this year has gone well.
"We've got a great bunch of guys and support staff as well. Fortunately, we came here as the number one ranked team."