Australia wicketkeeper Brad Haddin has confirmed he will not return to the tour of the West Indies after returning home for personal reasons.
Haddin's understudy in the original squad, Matthew Wade, is now almost certain to make his Test debut.
New South Wales gloveman Peter Nevill, who headed to the Caribbean following Haddin's recent return home, will stay on for the rest of the tour.
Haddin, 34, originally travelled to the West Indies with Australia's limited-overs squad before returning home.
And while Cricket Australia initially suggested there was hope he would return to the Caribbean in time for the first Test at Kensington Oval from April 8, they have since revealed he will be staying at home for "family reasons".
"Cricket Australia fully supports Brad's decision to remain in Australia and sends its best wishes to him and his family at this time," said Pat Howard, Cricket Australia's general manager for team performance.
Meanwhile, Test skipper Michael Clarke will leave Australia for the Caribbean on Sunday morning to continue his rehabilitation from a hamstring injury.