Wicketkeeper Tim Paine and all-rounder John Hastings have been ruled out of Australia's limited-overs teams for next month's tour of South Africa.
The duo both require surgery on injuries which will rule them out of two Twenty20 and three one-day internationals, which get under way with the opening T20 clash in Cape Town on October 13.
Wicketkeeper-batsman Paine has been struggling with a long-term finger injury and Australia team physiotherapist Alex Kountouris said: "Tim Paine injured his right index finger batting at training with his Tasmanian state team four weeks ago.
"He sustained a fracture in a similar part of the same finger late last year and required surgery.
"Tim has been resting the injury in recent weeks but is still experiencing considerable pain. His surgeon has advised that the fracture is healing slower than expected and may not heal without surgical intervention. As such, Tim will be undergoing surgery later this week.
"He is likely to need an extended recovery period following surgery and will not be available for selection for the T20 and ODI tour of South Africa."
All-rounder Hastings picked up a shoulder injury with his state side after returning from Australia's tour of Sri Lanka and has been ruled out for an unspecified period.
"He has had ongoing shoulder pain since this incident and has been unable to return to training," Kountouris explained.
"He has consulted a surgeon who has recommended surgery. It is possible that he will have surgery sometime in the next week after further assessment from the surgeon.
"His return to cricket will be dependent on the management approach pursued."