Ant Botha and Naqaash Tahir will both leave Warwickshire at the end of the season.
In Botha's case he will be retiring after a lengthy battle with an elbow injury, while Tahir has been told he can leave Edgbaston after an 11-year stay.
Botha joined the Bears from Derbyshire in 2007 and has been a regular ever since, while Tahir has been around the first-team squad for close to a decade.
"We are desperately sorry to see Ant forced out of the first-class game under these circumstances, as he has played an important part in our success over the past four years," said director of cricket Ashley Giles.
"Naqaash has been with us for many seasons since joining the squad as a young player via the development system at Edgbaston.
"It is sad to see him leave the club, but he has struggled to maintain a regular place in the side throughout this period."