Ajmal Shahzad was ruled out of England's crunch World Cup clash with West Indies because of a recurrence of a hamstring injury.
The Yorkshire seamer had a scan on his left leg on Wednesday night and the results not only ruled him out of the game in Chennai but, if England should progress through to the knockout stages, also the rest of the tournament.
England have said they will only consider calling up a replacement if they beat the West Indies in their final Group B fixture.
Despite losing Shahzad, England still opted to drop James Anderson from their starting XI following the defeat to Bangladesh last Friday.
Paul Collingwood was also left out, with fellow all-rounder Luke Wright drafted in. Off-spinner James Tredwell took the place of the injured Shahzad, while Chris Tremlett was preferred to the out-of-sorts Anderson.
All three newcomers were making their first appearances at the World Cup.