Australia will be without key duo Doug Bollinger and Mike Hussey for the third and final one-day international against India on Sunday.
Pace bowler Bollinger, who has missed the last two competitive matches, is struggling with a minor abdominal injury, while Hussey has been rested.
Both players will now return home and rest ahead of a crunch Ashes series with England.
Cricket Australia physio Kevin Sims said: "Doug reported some minor discomfort to his abdomen during his rehabilitation from a previous injury.
"We do not think the new issue is serious however it will prevent him from achieving the workloads necessary for him to be available for selection in the third one-day match in Goa.
"Therefore we have decided it is in his best interests to return to Australia for further assessment and to outline further rehabilitation. Doug's return-to-cricket date will be finalised following this assessment."
The absence of both men leaves Australia facing an uphill battle if they are to square the ODI series 1-1 on Sunday.