England's most successful Test captain Michael Vaughan is to hold a press conference on Tuesday where it is expected he will announce his retirement.
The Ashes-winning skipper resigned from the helm in August 2008, having led the country to more Test victories - 26 - than any other England captain.
He had hoped to regain his England place this summer and have another go at reclaiming the Ashes, as he did when leading England in 2005.
But a lack of runs and his inability to complete a day in the field this season because of a right knee injury is believed to have prompted Vaughan's decision.
"Without going over old ground, Michael had set his stall on being picked for the Ashes Tests," Yorkshire chief executive Stewart Regan said.
"That was what we and Michael were focused on. We agreed with the ECB we would give Michael every opportunity to get selected for the Ashes squad.
"When that didn't happen I think it then opened up a different set of thought processes over what happens next.
"He will discuss his future with his employers tomorrow and a press conference will be held on Tuesday."
The 34-year-old was omitted from Yorkshire's side to play Derbyshire in the Twenty20 Cup on Sunday, meaning he might have already played his last game for the county.
Vaughan played in 82 Tests for his country, scoring 5,719 runs and 18 centuries. He rose to number one in the ICC Test batting rankings after scoring three hundreds on the 2002-03 Ashes tour.