Brett Lee has been left out of Australia's squad for the one-day series against Pakistan in the United Arab Emirates after failing to overcome an ankle injury.
The New South Wales fast bowler, 32, will continue his rehabilitation in South Africa with a view to joining Australia's squad in the later stages of the series if deemed fit to do so.
He has been replaced by Doug Bollinger for the five one-dayers and solitary Twenty20 international, which are taking place on neutral territory due to security concerns in Pakistan.
"Brett's ankle has recovered well from surgery in January this year. However, the rehabilitation process is ongoing and, to date, Brett has not bowled sufficiently to allow him to be fit to resume playing cricket," Australia team physiotherapist Alex Kountouris said.
"I will be monitoring Brett's progress to assess his availability for any part of the VB series against Pakistan in the UAE."
Cricket Australia are keen to give Lee as much time as he need to regain 100 percent fitness, particularly as June's World Twenty20 in England is followed by Australia's defence of the Ashes.
"While it's disappointing for Brett to miss the start of the VB Pakistan series, the NSP (National Selection Panel) wants to take a careful approach to his return to the Australian team," chairman of selectors Andrew Hilditch added.
"Doug was probably a bit disappointed not to get a run during the Test series in South Africa, but this is an opportunity for Doug to impress at one-day level for Australia and I'm sure it's an opportunity he'll be keen to make the most of."
The series opener against Pakistan takes place in Dubai on April 22.