South Africa all-rounder Justin Ontong will miss the next two one-dayers against the West Indies due to a knee injury.
Better news for the Proteas comes with the news that skipper Graeme Smith is due to be fit to play in both matches after recovering from a knee injury.
The hosts won the first one-day international against the Windies by six wickets, but they still look set to make changes for the second match in Cape Town.
Coach Mickey Arthur confirmed that Ontong was out, but Smith is back, while paceman Dale Steyn has a hamstring worry.
"Justin tweaked his knee during the Pro20 game on Friday, and though he played through the pain on Sunday, he will not be available for selection for the next two matches," Arthur said.
"However, Graeme (Smith), who also has as bit of a knee injury, will be fine. He's a tough character.
"We'll monitor Dale Steyn's hamstring injury but he's looking good."
Arthur hinted that there could be changes for Friday's game, with Morne Morkel and a spinner two options for change.
"We'd like to give Morne (Morkel) some more game time, but if we select him for Friday, there will be another bowler who will be very unlucky not to play," Arthur added.
"We're still not sure of the make-up of the team for Friday, but we will probably play a spinner here."