Danny Garcia will make the fifth defence of his WBC and WBA light-welterweight titles against Mauricio Herrera in Puerto Rico.
Garcia's parents are from the islands and he will fulfill a career-long ambition when he clashes with Herrera in Bayamon on March 15.
It will be a step down in opponent for the Philadelphian after victories over Zab Judah and Lucas Matthysse in 2013.
However, Herrera (20-3) has a stellar victory over hard-hitting Ruslan Provodnikov in 2011 on his ledger and put successive losses a year later behind him with back-to-back wins in 2013.
"Herrera is a good fighter and he beat Provodnikov," Richard Schaefer of Golden Boy Promotions told ESPN. "Herrera is very excited about this fight.
"He sees it as a tremendous opportunity and is not worried at all about fighting Danny in Puerto Rico.
"(Danny) is clearly the man at 140 pounds and when you are the man you have a big target on your back.
"Whether Mauricio Herrera will be able to do something about it I don't know. But I do know Mauricio Herrera comes to fight and will be ready."
The same show will see unbeaten heavyweight Deontay Wilder take on former Dereck Chisora foe Malik Scott, while Juan Manuel Lopez will clash with Daniel Ponce De Leon in a featherweight re-match of their 2008 super-bantamweight bout that saw Lopez win his first world title with an early knockout.