Anthony Joshua has been forced to pull out of Saturday's ExCel Arena show due to a shoulder injury.
The Olympic gold medallist was going to top the bill with his fourth professional fight against Dorian Darch in London, live on Sky Sports 1.
But having been forced out of the Carl Froch-George Groves undercard with injury recently, a shoulder problem means the heavyweight will not return to the ring until the new year.
However, this Saturday's bill now includes Paul Smith.
The British super-midddleweight champion is now one of the biggest names on a busy night in the capital.
Kevin Mitchell takes on Italian Brunet Zamora for the vacant IBF Inter-Continental title while recent world welterweight challenger Lee Purdy aims to take the European title from Italian Leonard Bundu, in his fifth defence.
Joshua's Olympic teammeate Anthony Ogogo will get his fourth pro fight under his belt, while former world bantamweight champion Jamie McDonnell, Martin Murray and the highly-rated Khalid Yafai are also in action.
Elsewhere another British heavyweight star, David Price, has also been ruled out of his fight this weekend.
The Olympic bronze medallist was down to make his debut under new trainer Adam Booth and new promoters, the Sauerlands, in Germany, but has been struck down with a virus.