Carl Frampton has been forced to pull out of his fight at Wembley Arena on Saturday due to an ear problem.
The unbeaten 26-year-old from Belfast was due to defend his IBF intercontinental super-bantamweight title against Everth Briceno of Nicaragua.
Frampton had originally been due to fight Fabian Orozco, but the Argentinian suffered an upset defeat and the dangerous Briceno had been drafted in as a replacement.
However, that bout will not take place after the British Boxing Board of Control deemed Frampton was not fit to box after an old ear injury reoccurred.
Frampton tweeted: "I'm upset to have to announce that I have been ruled out of my fight on Saturday by the BBBoC. An old ear injury mildly reoccured in a spar.
"A specialist initially informed me I was fit to box. Today the BBBoC ruled me out. I'm so so sorry especially to the people who were coming to support me.
"It's been an amazing camp and I'm gutted that I won't be able to showcase my improvements in Wembley."
Frampton's trainer Shane McGuigan tweeted: "Unfortunately today Carl Frampton was overruled by the BBBofC that he cannot box this Saturday due to an old ear injury.
"We were passed fit by another source but today the BBBofC ruled us out. We as a team are bitterly disappointed by this decision.
"We've made some amazing improvements this training camp & will build on everything for a hopeful world title shot soon! Carl is gutted he can't fight for his fans!"